Surp and g-patch domain-containing protein 14

Protein annotations for g patch domaincontaining protein. Stress granules and processing bodies share rna and protein components, both appear under stress, and can physically associate with one another. Gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14. Order us biologicals antisfrs14, ct azide free apc sku. Putative splicing factor, arginineserinerich 14 is a protein that in humans is encoded by the. An additional 14 spliceosomeassociated proteins were detected below the cutoff used for the data in. Sugp2 surp and g patch domain containing 2 house mouse. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

Sugp2 surp and gpatch domaincontaining protein 2 homo. Loc103330493 surp and gpatch domaincontaining protein 1. Protein name surp and gpatch domaincontaining protein 2 100% guarantee bethyl guarantees that its products will work under the same conditions stated on the product datasheet. More data hpa041557 rabbit anti surp and gpatch domain containing 2 antibody. Among its related pathways are mrna splicing major pathway. Putative splicing factor, arginineserinerich 14 is a protein that in humans is encoded by the sfrs14 gene references. Sfrs14 products available through novus biologicals. Diseases associated with gpatch2 include lymphogranuloma venereum and granuloma inguinale. Apercu des produits pour antisplicing factor 4 anticorps. Surp and gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14, putative splicing factor, arginineserinerich 14, serineargininerich splicing factor 14, splicing factor, arginineserinerich 14. Sampson and hewitt 2003 also cloned the mouse orthologs.

We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep insight case reports journals portal teaching. Promotes the utilization of a cryptic splice site created by the beta110 mutation in the hbb gene. Wikigenes sugp1 surp and g patch domain containing 1. Validated for immunofluorescence, immunohistochemistry and western blot. Loc114459751 surp and gpatch domaincontaining protein 1like bluntsnouted clingfish gene id. Surp and gpatch domaincontaining protein 2 mus musculus 118 975.

The function of two helicases from this family, prp2 and prp43, is regulated by protein partners containing a gpatch domain. Two additional proteins containing surp domains were found by coip table 1, the u2 snrnpassociated surp motifcontaining protein u2surpsr140 and the a complex component surp and gpatch domaincontaining protein 1 sugp1sf4. Predicted intracellular proteins intracellular proteins predicted by mdm and mdsec mapped to nextprot nextprot evidence at protein level protein evidence peptideatlas show all. Insul8 qtl report rattus norvegicus rat genome database. Sugp2 surp and g patch domain containing 2 synonyms. Sf4 and sfrs14, two related putative splicing factors on. Several groups of gpatch containing proteins are conserved in animals, plants and fungi. Tm6sf2 is located on chromosome 19 precisely at locus 19p.

Sugp1 surp and gpatch domaincontaining protein 1 mus. Protein name surp and gpatch domaincontaining protein 2. Sugp2 protein expression summary the human protein atlas. Sugp2 surp and gpatch domain containing 2 northern. Sugp1 surp and gpatch domain containing 1 is a protein coding gene. Pdf sugp1 is a novel regulator of cholesterol metabolism. It has a domain involved in rna processing and modification, a c2h2type zinc finger, an rgd motif, a nuclear localization signal, and sites for amidation, myristoylation, lipidation, nglycosylation, glycosaminoglycan attachment, and phosphorylation. We identified the proteins by mass spectrometry and found that levels of the spliceosomal protein sugp1 surp and gpatch domain containing 1 were greatly reduced in the mutant sf3b1 spliceosome. Sensing of alzheimers disease and multiple sclerosis using. Browse our splicing factor, arginineserinerich 14 proteins. Sfrs14, srsf14 gene nomenclature, locus information, and go, omim, and pmid associations are updated daily from mgi. Tbl2 transducin betalike protein 2 in homo sapiens.

Both sf4 and sfrs14 contain 2 surp motifs and a single gpatch domain in their c termini. The resulting frameshift leads to sickle cell anemia. Tested in western blot wb and immunoprecipitation ip applications. Protein protein interactions application by cisbio. Mammalian splicing factor sf1 interacts with surp domains of. Recently, it was reported that hotspot mutations in sf3b1 specifically disrupted the interaction with the spliceosomal protein, surp and the gpatch domaincontaining 1 sugp1, without the. Sfrs14 encodes a deduced 1,083amino acid protein with an estimated molecular mass of 120. Sugp1 surp and gpatch domaincontaining protein 1 homo. Surp and gpatch domaincontaining protein 1 recommended applications product description stable isotopelabeled standard for absolute protein quantification of sugp1.

Search thousands of articles and collaborate with scientists around the globe. Sugp2 surp and gpatch domaincontaining protein 2 mus. This gene encodes a member of the arginineserinerich family of splicing factors. Surp and gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14, putative splicing factor, arginineserinerich 14, serineargininerich splicing factor 14. Produktubersicht splicing factor, arginineserinerich 14. Complete information for sugp1 gene protein coding, surp and gpatch domain containing 1, including. Sorted by availability of experimental interaction data e. Sfrs14 also contains an arginineserinerich n terminus, suggesting that it is a novel member of the srrelated family of premrna processing factors. Alternative names arginine serinerichsplicing factor 14.

Surp and gpatch domaincontaining protein 1like protein. Sugp1, surp and gpatch domain containing 1 vertebrate orthologs 10 human ortholog sugp1, surp and gpatch domain containing 1. Probable component of an e3 ubiquitin protein ligase complex, in which it may act as a substrate recognition subunit. Surp and g patch domain containing 2 sugp2 antibody. Sugp2, surp and gpatch domain containing 2, sfrs14, kiaa0365, 19p. Omim entry 614396 gpatch domaincontaining protein 8. Hect and rld domain containing e3 ubiquitin protein ligase 4. In some of these proteins the g patch is the only recognisable domain but in most of them it is combined with other domains, which include welldefined rnabinding domains, such as the rrm, dsrbd, surp and r3h. Loc114459751 surp and gpatch domaincontaining protein 1. As of 2018, of the 660 proteins identified as localizing to stress granules, 11% also have been identified as processing bodylocalized proteins see below.

Sfrs14 and sf4 contain gpatch domains at their ctermini. Imagine a global collaborative knowledge base for original thoughts. Rbm10, rna binding motif protein 10, s11, dxs8237e, kiaa0122, zranb5. Surp and gpatch domaincontaining protein 2, splicing factor, arginineserinerich 14, splicing factor, arginineserinerich 14. It is flanked by sugp1 a surp and gpatch domaincontaining protein thought to play a role in premrna splicing and hapln4 a hyaluronan and proteoglycan link protein 4 that binds to hyaluronic acid and may be involved in formation of the extracellular matrix genes upstream and downstream respectively.

Diseasecausing mutations in sf3b1 alter splicing by. Alternatively spliced transcript variants have been described. Sugp2 surp and gpatch domain containing 2, authors. Loc103330493 surp and gpatch domaincontaining protein 1like protein japanese apricot gene id. Sugp1 is a novel regulator of cholesterol metabolism human. Both sf4 and sfrs14 contain 2 surp motifs and a single gpatch domain in. Mammalian splicing factor sf1 interacts with surp domains.

Arginineserinerichsplicing factor 14 antibodies from 18 suppliers. Determining the function of the surp motif will be required to investigate this possibility. Gene ontology go annotations related to this gene include nucleic acid binding. Alternative names arginineserinerichsplicing factor 14. Rna helicases from the deahrha family are present in all the processes of rna metabolism. Gene names and symbols associated with splicing factor 4 proteins sf4 surp and gpatch domain containing 1 sugp1 antibody surp and gpatch domain containing 1 sugp1 antibody.

Among its related pathways are gene expression and mrna splicing major pathway. It is flanked by sugp1 a surp and gpatch domaincontaining protein thought to play a role in premrna splicing and hapln4 a hyaluronan and proteoglycan link protein 4 that binds to hyaluronic acid and may be involved in formation of the extracellular matrix genes upstream and downstream. Gpatch2 gene genecards gptc2 protein gptc2 antibody. Aliases sugp2, sfrs14, surp and gpatch domain containing 2, srfs14. Q9ui333 isoform 3 of sodium channel protein type 11 subunit alpha 22 0 1. Sf4 and sfrs14, two related putative splicing factors on human chromosome 19p. Surp and gpatch domaincontaining protein 1 gene id species. The gpatch is a glycinerich domain discovered by sequence alignment, involved in protein protein and protein nucleic acid interaction. Diseases associated with sugp1 include louping ill and osteogenesis imperfecta, type i.

Sugp2 surp and gpatch domain containing 2 is a protein coding gene. Gpatch domain containing gpatch gene family hugo gene. Sugp2 surp and g patch domain containing 2 house mouse gene id. Thus, it is likely that the surp modules within a single protein are not functionally homologous and perhaps may bind to distinct proteins or to two distinct sites of a single interacting protein. Splicing factor, arginineserinerich 14 sfrs14 antibodies. Gene ontology go annotations related to this gene include nucleic acid binding and rna binding. We used affinity purification to isolate spliceosomal complexes associated with either wildtype wt or the hotspot k700e mutant sf3b1. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep. Sugp2 surp and g patch domain containing 2 is a protein coding gene. Group gene id gene protein id tot tp sc tp sc description mass pep kevin.

Table1, 1, the u2 snrnpassociated surp motifcontaining protein u2surpsr140 and the a complex component surp and gpatch domaincontaining protein 1 sugp1sf4. Sugp2, surp and gpatch domain containing 2 vertebrate orthologs 8 human ortholog sugp2, surp and gpatch domain containing 2. General description splicing factor 4 surp and g patch domain containing 1 sf4, rbp, sugp1 is closely related to sfrs14 arginineserinerich splicing factor 4 which is a potential normalization protein for gene expression studies in hcv. Interpro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. Gpatch2 gpatch domain containing 2 is a protein coding gene. Antig patch domain and kow motifscontaining protein antibody produced in rabbit, antig patch domaincontaining protein 5 antibody produced in rabbit, anti protein mos2 homolog antibody produced in rabbit, anti protein t54 antibody produced in rabbit. Hect and rld domain containing e3 ubiquitin protein ligase 2. Ipr040169 surp and gpatch domaincontaining protein 12. Ontomate literature search jbrowse genome browser variant visualizer multiontology enrichment moet geneortholog location finder golf interviewer protein protein interactions phenominer quatitative phenotypes gene annotator olga gene list generator ratmine gviewer genome viewer overgo probe designer acp haplotyper genome scanner. Sensing of alzheimers disease and multiple sclerosis using nanobio interfaces.